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Transmission
of the HIV
The
HIV is shown to be readily transmitted through sexual contact, exposure
to blood and/or blood products and certain body fluids. Studies indicate
the highest percentage of the HIV transmissions occur during sex acts
where body fluids are exchanged. Body fluids should be interpreted as
blood, blood products, saliva, tears, urine, semen, vaginal secretions,
breast milk, and perspiration. The use of contaminated needles by injecting
drug use is the second most frequent route of transmission of the HIV.
The accepted perspective of the transmission and prevention of the HIV
is based on two distinct findings.
First,
it has been revealed that the HIV can be transmitted through infected
blood or semen. Additionally, the production of an overt disease by a
transmitted virus seems to demand additional conditions such as a significant
level of infection or repeated exposure. As a result and one that can
be predicted, the HIV spreads through persons who engage in risky behavior
where these conditions are most likely to be met. HIV can also be transmitted
from pregnant women to their unborn babies during the birthing process.
Preventing
the Spread of the HIV
People
are demonstrating concern regarding this life-threatening disease that
so far has eluded a cure. These fears are usually out of proportion to
the actual risks revealed by scientific studies. The known facts are now
being presented by groups, counseling, neighborhood education programs,
mass communication media and other concerned individuals in an intense
effort to educate the general public concerning the facts about AIDS and
the HIV. The following list offers some of the ways the HIV is NOT transmitted:
- The HIV is not spread by shaking hands or otherwise touching someone
who is HIV positive.
- The HIV is not spread by insect bites such as those inflicted by mosquitoes.
- The HIV is not spread by sharing eating utensils with someone who
is HIV positive.
- The HIV is not spread by sharing drink glasses or cups.
- The HIV is not spread by kissing although some researchers advise
avoiding "deep kissing."
To
prevent HIV infection CDC offers the following suggestions:
- Do not have sex with an infected person.
- Do not share needles with an infected person.
- Avoid behavior that might result in contact with blood, semen, vaginal
secretions, or body fluids with visible blood.
- Specifically, avoid sex with anyone who might be infected with HIV,
and do not share "injecting drug works."
The
following prevention measures apply to personal sexual practices and injecting
drug use (IDU):
- To prevent sexual transmission of HIV, abstain from sex with an infected
person.
- Ask about the sexual history of current and future sex partners.
- Reduce the number of sex partners to minimize the risk of HIV infection.
- Always use a condom from start to finish during any type of sex (vaginal,
anal, and oral). Use latex condoms rather than natural membrane condoms.
If used properly, latex condoms offer greater protection against sexually
transmitted diseases, including HIV.
- Use only water-based lubricants. Do not use saliva or oil-based lubricants
such as petroleum jelly or vegetable shortening. If you decide to use
a spermicide along with a condom, it is preferable to use spermicide
in the vagina according to manufacturer's instructions.
- Avoid anal or rough vaginal intercourse. Do not do anything that would
tear the skin or moist lining of the genitals, anus, or mouth and cause
bleeding.
- Condoms should be used even for oral sex.
- Avoid deep, wet, or "French" kissing with an infected person. Even
though transmission of HIV has not been documented by this method, possible
trauma to the mouth may occur, which could result in the exchange of
blood.
- Avoid alcohol and illicit drugs. Alcohol and drugs can impair your
immune system and your judgment. Do not share needles, syringes, cookers
- "works".
- Do not share personal items such as toothbrushes, razors, or devices
used during sex which may be contaminated with blood, semen, or vaginal
fluids.
- If you are Infected with HIV or have engaged in sex or needle-sharing
behaviors that lead to infection with HIV, do not donate blood, plasma,
sperm, body organs, or tissues.
Reducing
high risk behavior through educational efforts is still the best way to
prevent HIV infections.
What's
My RISK?
Any
one of the following behaviors can put you at risk for contracting the
AIDS virus.
- Unprotected sex with someone whose HIV status you didn't know.
- Unprotected sex with someone you knew was HIV positive or had AIDS.
- Unprotected sex with multiple partners or with someone who has had
unprotected sex with multiple partners.
- Unprotected sex with someone who uses needles to take drugs.
- Use of drugs (heavy alcohol, barbiturates, sedatives, etc.) which
could have affected your ability to remember whether or not you had
unprotected sex.
- Having a sexually transmitted disease such as genital herpes or warts,
gonorrhea, syphilis, chlamydia, etc.
- Sharing needles with another person.
- Mother was HIV positive when she was pregnant with you.
- Having had an open wound or cut that was exposed to another person's
body fluids, such as blood or semen.
- Had a blood transfusion before March 1985.
Diagnostic
Tests
Testing
is an important tool in the nation's efforts to curtail the spread of
HIV. Testing allows researchers to track the course of the epidemic, and
provides information to help in developing prevention strategies and allocating
resources for HIV-related services. Counseling which should be provided
before and after testing, provides a unique opportunity to educate individuals
about HIV, including risks, how to avoid infection, and if they are positive,
how to protect others, and treatment options and follow-up.
In
addition to its value as a prevention tool, testing is the first step
in helping people who are infected receive appropriate treatment. Early
detection of the HIV, followed by certain drug combinations, can greatly
improve both the quality and quantity of life. It also plays a vital role
in reducing the transmission of HIV from mother to infant. Pregnant women
who are tested and find out they are infected have the opportunity to
take drugs which may prevent the infant from becoming infected.
The
primary means of documenting HIV infection is by HIV antibody testing
and viral culture. Viral cultures are both expensive and time consuming,
so antibody testing is the method of choice for rapid and inexpensive
confirmation of HIV exposure. You should be aware that antibody testing
alone is not diagnostic for AIDS. As early as 1985 the enzyme-linked immunoabsorbent
assay (ELISA) test was available. It is a commercial test used for many
purposes other than the detection of HIV antibodies. The ELISA test is
not a test for AIDS and it does not detect the actual virus but only indicates
that there is the presence of antibodies to the HIV.
The
reliability of the ELISA test is high and it is considered sensitive and
specific. The Centers for Disease Control and Prevention estimates the
sensitivity and specificity of the licensed ELISA tests are 99% or higher
when the double ELISA test is done.
The
Western blot technique is one that uses electrophoresis to separate viral
antigens and measures serum antibody reaction to specific viral proteins
(core and envelope proteins).
HIV
testing can also be done with saliva. The FDA has approved the first test
that uses a saliva sample rather than blood. Marketed under the name of
Ora SureT, the test kit consists of a cotton swab on a stick and a vial
containing a preservative solution. The client holds the swab between
the lower cheek and gums for two minutes; then, the entire stick is put
into the vial and sent to the lab. The test is not intended or approved
for home use.
Because
the test produces false negatives or false positives in up to 2% of clients,
it is considered less accurate than the standard blood test for HIV. As
a result, it is not approved for screening potential blood donors. Furthermore,
the FDA requires positive results to be confirmed by a blood test.
A
new alternative in HIV testing can now be performed conveniently, in the
comfort and privacy of the home. Home AccessT HIV testing provides fast
test results that are just as reliable as those used by doctors, hospitals,
and public clinics. Everything needed for an accurate result is included.
Also,
the option to speak with a professional counselor 24 hours, 7 days a week
is available. This self-administered test is complete in 4 short steps.
- Call to register a code number and receive pre-test information.
- Collect a blood sample by pricking a finger with a safety lancet.
Then apply blood to a specimen collection card.
- Package the specimen card and ship to Home AccessT laboratory.
- Call for the results. Blood is screened using the ELISA system. If
this screen is positive, a more specific confirmatory test, Immunoflouresence
Assay (IFA) will be used. Home AccessT guarantees anonymity with every
call. No names are ever associated with a test result. This test kit
can be ordered over the Internet at www.hiv-test.net.
FYI:
Fewer than 40% of people in the U.S. who are potentially at risk for HIV
infection have been tested! You should be aware that neither the CDC nor
WHO endorsed universal mandatory testing at any time. The suggestion has
also been rejected by the American Nurses Association (ANA).
Despite
the myths and half-truths that exist concerning the HIV and AIDS,and if
recommended precautions are taken and the caregiver doesn't succumb to
unrealistic fears, adequate protection from the virus will be achieved.
The best approach to avoid contracting AIDS or the transmission of the
HIV is the CDC's recommendation of Standard Precautions: to treat every
client as though they are HIV positive. This recommendation is repeated
numerous times within this course and its importance cannot be overemphasized.
OSHA
law, which protects healthcare workers, requires the practice of Universal
Precautions. CDC broadens this to include taking precautions with ALL
body fluids and substances. This expanded definition is known as Standard
Precautions.
Standard
Precautions
The
experience of treating a client with AIDS often presents the health professional
with a dilemma. The question often arises as how to best protect ourselves
and others in the daily requirements of our responsibility to clients
and not contribute to a feeling of discrimination? Using Standard Precautions
suggested by the CDC, you can best protect yourself and others as you
provide care by treating all clients equally.
The
Standard Precautions requirement is, of course, applicable in emergency
care situations or in those areas where there is a high risk of exposure
to blood or body fluids. It is in those situations the risk of being exposed
to contaminated blood or body fluids is greatest. These precautions are
designed to prevent the transmission of pathogens from all body substances
such as:
- blood
- all body fluids, secretions, and excretions (except perspiration)
regardless of whether or not they contain visible blood
- non-intact skin
- mucous membranes
The
Caregiver and Special Precautions
During
early attempts to find treatment or at the very least, control the HIV,
numerous treatment and control techniques were suggested. Special isolation
procedures would only be necessary if associated conditions such as infectious
diarrhea, tuberculosis or other communicable diseases were present. Therefore,
Standard Precautions carried out by all healthcare workers (HCWs) are
as follows:
Handwashing
- Hands should be washed for 15 seconds using soap and water, rinsing,
and using paper towels to turn off the faucet. Hands must be washed before
any patient contact and after any contact with body substances as listed
above as well as any contaminated items or linens used by patients. Hands
must be washed before and after the use of protective gloves, and after
the caregiver's use of the toilet and before and after the caregiver eats
or takes beverages.
You
should also be aware of the dangers of placing fingers or other items
in the mouth, rubbing the eyes, or eating and drinking in any environment
which may be contaminated. HANDWASHING IS THE SINGLE MOST IMPORTANT FACTOR
IN PREVENTING HIV OR OTHER DISEASES.
Barrier
Precautions - Health-care professionals should always use barrier
precautions to prevent skin or mucous membrane exposure to blood or body
fluids.
Gloves
- Latex or vinyl gloves must be worn before touching any blood, body fluids,
excretions, non-intact skin, or mucous membranes. Gloves should be changed
between patients and between tasks for the same patient if in contact
with material that may spread the organisms to other body parts. They
should also be worn when performing venipuncture or other vascular access
procedures. With the possibility of undetectable holes in exam gloves,
and in an effort to improve overall safety, many healthcare professionals
elect to double-glove for the above procedures. Always examine gloves
closely before wearing.
Protective
Equipment - Use a mask and eye protection or a face shield when performing
procedures where splashing of blood, body fluids, or secretions and excretions
may occur.
Gowns
- Wearing a clean, non-sterile gown can protect the caregiver from soiling
of clothing during patient procedures where body fluids may contaminate.
Saliva
- Although it has not shown to be implicated in the transmission of the
HIV, saliva has not been removed from the list of body fluids that require
the caregiver to exercise standard precautions. The CDC suggests in instances
of resuscitation, mouthpieces, resuscitation bags or other ventilation
devices should be readily available. In all clinical settings the CDC
and the American Dental Association's Council on Dental Therapeutics suggest
that saliva contaminated with blood can potentially carry the HIV.
Patient/Resident
Equipment - Use Standard Precautions when handling, discarding, or
cleaning any medical equipment. Although the HIV is considered fragile,
(it has been shown to be easily destroyed by exposure to common cleaning
agents, and by all routine methods of sterilization presently used in
hospitals and clinics) Hepatitis B Virus (HBV) may live for several weeks
on equipment, furniture, and linens.
Environment
- Facility policy should dictate routine and proper cleaning and disinfecting
of walls, floors, bed and bedside furniture, and any other frequently
used items.
Sharps
and Needle Stick Protection - While HIV infection is rare among caregivers
there is the potential for exposure any time a puncture wound occurs from
a contaminated needle, lancet, or surgical instrument. Special care should
be taken when using, caring for, or disinfecting, or cleaning these items.
Needles should NEVER be recapped with both hands, purposely bent, broken,
manipulated, or removed from disposable syringes by hand.
After
use, disposable syringes and needles, scalpel blades, and all other sharps
that are to be disposed should be placed in a puncture-resistant container
that is placed as close to the use area as is practical. Large bore reusable
needles should be placed into a puncture-resistant container and then
transported to the nearest reprocessing area. Housekeepers and other environmental
workers must adhere to the same precautions when disposing of contaminated
rubbish.
Exercise
Caution!
HCWs
must take precautions to avoid becoming infected by accidental parenteral
incidents. Nurses, phlebotomists, physicians, laboratory workers, paramedics,
housekeepers and laundry workers, and others with a one-to-one patient
contact may inadvertently infect themselves by accidental stick from a
needle or lancet, cut by a surgical instrument, or having blood or body
fluids splashed into mucous membrane or non-intact skin.
The
documented instances of transmission of the HIV to a practicing caregiver
have been low in spite of the number of personal contacts between clients
who have AIDS. This can most probably be attributed to the caregiver's
education, training, attention to detail and procedure along with following
standard precautions have all contributed significantly to these statistics.
However,
in an attempt to prevent even one additional contracted case occurring,
you should personally be concerned and dedicated to avoiding personal
injury in your caregiving environment.
The
CDC has determined that the needle stick injury is most often the result
of inadequate attention to detail by the caregiver during the accomplishment
of a procedure.
Research
has revealed that the use of protected needles or needleless equipment
will significantly decrease the chances that nurses or other HCWs will
obtain needlestick injuries.
Safe-working
practices are the first priority. Immediately after use, contaminated
needles and other sharps must be disposed of in an approved container
as near to the care area as possible. This container must be puncture-resistant,
leak-proof, color-coded, and labeled with the biohazard label. NEVER bend,
recap with two hands, or break needles or other contaminated sharp items.
Needle safety devices are available. If you MUST recap, use the one-handed
scoop method only.
Specimens
should be placed in leak-proof containers or bags with a biohazard warning
label. Appropriate procedures must be followed for cleaning and sterilizing
instruments. Never reuse disposable equipment.
About
one out of every four needlestick injuries involves IV therapy equipment.
Many injuries result during disassembly, but they may also occur during
steps of the assembly/use/discard process, including insertion into drip
chambers, injection ports and IV bags.
You
should also be aware that needles attached to discontinued IV lines may
also present a problem. The federal government offers sanctions to discourage
health facilities from continuing to use conventional devices. It is documented
that Occupational Safety and Health Administration (OSHA) has levied fines
against hospitals for failure to evaluate and consider the adoption of
engineering controls, equipment or devices that reduce the risk of needlestick
injury.
Management
of Infected Caregivers
There
have been only a few instances where the HIV has been transmitted from
a caregiver (only a dentist in Florida, to date) to a client, but there
is an ever-present possibility it can occur during an invasive procedure.
You should be aware that transmission of the Hepatitis B virus (HBV),
another blood-borne pathogen, is more easily transmitted. In all instances,
such transmissions occurred during invasive procedures when the caregiver
sustained a puncture wound or had exudative or weeping lesions or microlacerations
that allowed the virus to contaminate instruments or the open wounds of
clients.
The
CDC is aware of 54 healthcare workers in the US who have been documented
as having seroconverted to HIV following occupational exposures. Twenty-five
have developed AIDS. When the very high number of caregivers with a high
rate of exposure is considered, this number, although regrettable represents
an extremely low occurrence of the disease.
These
individuals who seroconverted include 22 nurses, 19 laboratory workers
(16 of whom were clinical laboratory workers), 6 physicians, 2 surgical
technicians, 1 dialysis technician, 1 respiratory therapist, 1 health
aide, and 1 housekeeper/maintenance worker and 1 embalmer/morgue technician.
(CDC, HIV Surveillance Report, 10(1), 24,1998)
UPDATE:
MMWR 1998; 47(No.RR-7) Public Health Service Guidelines for the Management
of Healthcare Worker Exposures to HIV and Recommendations for Postexposure
Prophylaxis (PEP)
This
summary information updates and consolidates all previous public health
service (PHS) recommendations for the management of health care workers
(HCWs) who have occupational exposure to blood and other body fluids that
may contain HIV; it includes recommendations for HIV postexposure prophylaxis
(PEP) and discusses scientific rationale for PEP. The decision to recommend
HIV PEP must take into account the nature of the exposure (e.g., needlestick
or potentially infectious fluid that comes in contact with a mucous membrane)
and the amount of blood or body fluid involved in the exposure. Other
considerations include pregnancy in the HCW and exposure to virus known
or suspected to be resistant to antiretroviral drugs. Assessments of the
risk for infection resulting from the exposure and the infectivity of
the source are key determinants of offering PEP. Consent from the possibly
infected patient (source of HIV) must also be given to test. Systems should
be in place for the timely evaluation and management of exposed HCWs and
for consultation with experts in the treatment of HIV when using PEP.
Recommendations
for PEP have been modified to include a basic 4-week regimen of two drugs
(zidovudine & lamivudine) for most HIV exposures. An expanded regimen
includes the addition of a protease inhibitor (indinavir or nelfinavir)
for HIV exposures that pose an increased risk for transmission; or where
resistance to one or more of the antiretroviral agents recommended for
PEP is known or suspected.
Occupational
exposures should be considered urgent medical concerns to ensure timely
administration of PEP. Health care organizations should have protocols
that promote prompt reporting and facilitate access to post-exposure care.
Enrollment of HCWs in registries designed to assess side effects in HCWs
who take PEP is encouraged. For the complete document on PEP recommendations:
Single
copies are available from the CDC, National AIDS Clearinghouse, PO Box
6003, Rockville, MD 20850, or (800) 458-5231 or online at www.cdcnac.org.
First-Line
Drugs for HIV (PEP)
Nucleoside
Reverse Transcriptase Inhibitors
Zidovudine (Retrovir; ZVD, AZT)
Dosage:
600mg QD divided doses
Side
Effects: Neutropenia, anemia, fatigue, malaise, HA, insomnia, asthenia.
Caution:
if coadministered with bone marrow suppressive drugs or cytotoxic therapy.
Lamivudine
(Epivir; 3TC)
Dosage:
150mg BID
Side
Effects: HA, abd. pain, diarrhea, & rare cases, pancreatitis. Toxicity
of AZT & 3TC in combo is equal to AZT alone.
ZDV
plus 3TC (Combivir)
Dosage:
1 tab BID; each tab contains 300mg ZVD and 150mg 3TC
Side
Effects: see above for ZVD & 3TC
Caution:
same as Zidovudine
Protease
Inhibitors (PIs)
Indinavir (Crixivan; IDV)
Dosage:
800 mg Q 8 h on an empty stomach
Side
Effects: Nephrolithiasis, crystalluria, hematuria, nausea, HA, indirect
hyerbillirubinemia, elevated liver function tests (LFTs), and hyperglycemia/diabetes.
Comments:
Nephrolithiasis may be reduced by consuming large quantities of water
(six 8oz. [tot. 48 oz.] throughout the day).
Nelfinavir
(Viracept)
Dosage:
750 mg TID with meals
Side
Effects: Diarrhea, hyperglycemia/diabetes.
Comments:
If oral contraceptives are used, alternative or additional contraceptive
measures should be used while taking nelfinavir.
There
are additional antiretroviral drugs used for PEP that may be considered
in special circumstances. They are listed as follows, and details may
be obtained in the complete document available from the CDC: Zalcitabine;
Didanosine; Stavudine; Ritonavir; Saquinavir; Nevirapine; Delavirdine.
Care
of the AIDS Client
AIDS
is a disease that presents a unique and challenging health, and life-threatening
problem for the client, as well as challenges for the caregiver. Clients
will require physical care, emotional support and counseling for a debilitating
disease. They will not only be aware the disease is fatal, but it also
may have been transmitted to a loved one. In many cases, your clients
are faced with the fact that AIDS is a stigmatized disease. You will find
the emotional responses and requirements for help and support will vary
with the inner coping and adjusting capabilities of each individual. These
are directly related to the inner strengths, beliefs and mental health
of each client. Your sincere, dedicated emotional support to AIDS clients
during this period cannot be overemphasized.
The
healthcare requirements for persons with AIDS will vary as the disease
progresses. These needs are met in a variety of ways, circumstances and
settings. During this time, the client's personal needs for providers
will also vary. Often a caregiver will be, the nurse, a home-health aide,
a family member, a friend or maybe another person with AIDS.
During
the course of the disease, your client may experience multiple hospitalizations
for treatment of acute, opportunistic infections. You may be the primary
provider during these episodes.
As
the disease progresses to its terminal stages, your client's family and
friends may act as the primary provider and perform the necessary care
in the client's home. During these periods your clients may also require
the assistance of a home-health aide.
In
the following sections we will discuss some important needs and requirements
of AIDS clients in a hospital care setting.
Hospital
Care of the AIDS Client
The
CDC has suggested special isolation for AIDS clients only if associated
conditions such as infectious diarrhea, tuberculosis or other communicable
diseases are present. With AIDS, these infections will often result in
severe illness due to an inefficient immune system. The AIDS client
who is admitted to the hospital will often be acutely ill, physically
debilitated and extremely apprehensive. One of your most important roles
in admission will be one of support and reassurance. As an initial step,
you can explain the necessity of having a complete physical examination,
various other procedures and diagnostic tests. A factor of extreme importance
and concern to the client is confidentiality.
During
the past decades the legislatures of many states have enacted strict HIV
testing and confidentiality laws. You must give assurance of strict confidentiality
of the information that is divulged and also assure the client this applies
to results of all diagnostic procedures and laboratory tests.
Hospital
care for AIDS is planned as with all other clients, on the basis of assessment.
The plan will focus first on the most critical problems which are usually
the opportunistic infections and malfunctioning organs or systems. Objectives
and treatment are to:
- Identify and treat infections.
- Maintain functioning organs.
- Provide symptomatic relief.
- Identify and/or prevent complications of treatment.
- Provide compassionate, emotional and physical support.
Current
Medical Pharmaceutical Treatment
Recent
years have marked major advances in AIDS treatment. For the first time
since the epidemic began, death rates have dropped in the US, in large
part because new drugs are helping patients live longer. These new drugs,
known as protease inhibitors, stop the virus from replicating. Crixivan
and Norvir, the first two powerful drugs of this class, came on the market
in 1996. These drugs are expensive and involve a complicated regimen of
up to 20 pills a day.
Protease
inhibitors are often used in combination "cocktails" with older drugs
called reverse transcriptase inhibitors. These drugs, which include AZT
and 3TC, may slow the spread of the HIV in the body and delay the onset
of opportunistic infections. Unfortunately, the virus can become resistant
to both classes of drugs.
In
addition the following drugs have been approved: Zidovudine (AZT), Crixivan
(idinaver), and Sustiva (efavirenz) and others listed previously under
the PEP section are in clinical use against HIV.
Antiretroviral
Agents: The Next Generation
Despite
dramatic progress over the past few years, antiretroviral therapy continues
to have limitations. Currently available drugs often have inconvenient
dosing schedules, high pill burden, significant side effects, and complex
drug-drug interactions.
In
addition, a growing number of patients no longer appear to respond to
current therapies. Thus, new antiretroviral agents are urgently needed.
Fortunately,
over the next year three new drugs are expected to become widely available:
abacavir (BU1592U89), adefovir dipivoxil (Preveon, bisPOM PMEA), and amprenavir
(141W94). In short-term studies, each drug appears to be safe, well tolerated,
and effective, particularly in treatment-naive patients.
Information provided by the Food and Drug Administration (FDA) states
there are presently more than 300 ongoing human studies sanctioned to
study drugs that may be used to treat AIDS or related conditions. Many
of these studies use two or more experimental therapies in combination.
The Administration advised that requests for information should be directed
to the sponsor of the AIDS Clinical Trials Information Service, which
can be reached by telephone at 1-800-TRIALS-A.
The
FDA has made drugs available under its Investigational New Drug (IND)
treatment program. This allows clients with serious or life-threatening
conditions for which there are no satisfactory treatments, to obtain promising
experimental drugs if clinical testing shows safety and effectiveness.
One
research development in its final stages is the three-year study conducted
by VaxGen, of San Francisco, CA. VaxGen has developed AIDSvax, the first
vaccine approved for testing in human volunteers. These trials are not
dangerous to the subjects because a live strain of the virus is not used.
The trials will be conducted on healthy people who are at high risk for
contracting the HIV virus, such as women and men who have sex with men
whose partners are infected. The trials will take four years to complete
at which time the FDA will make a decision to approve the vaccine for
use. |